Joseph T Coyle Selected Research

Glycine (Aminoacetic Acid)

1/2018	Astrocytes in primary cultures express serine racemase, synthesize d-serine and acquire A1 reactive astrocyte features.
1/2018	In Vivo Brain Glycine and Glutamate Concentrations in Patients With First-Episode Psychosis Measured by Echo Time-Averaged Proton Magnetic Resonance Spectroscopy at 4T.
2/2015	The NMDA receptor 'glycine modulatory site' in schizophrenia: D-serine, glycine, and beyond.
9/2014	Chronic D-serine reverses arc expression and partially rescues dendritic abnormalities in a mouse model of NMDA receptor hypofunction.
9/2012	NMDA receptor and schizophrenia: a brief history.
5/2012	Neuronal D-serine regulates dendritic architecture in the somatosensory cortex.
1/2011	Discordant behavioral effects of psychotomimetic drugs in mice with altered NMDA receptor function.
1/2007	Low cerebrospinal fluid glutamate and glycine in refractory affective disorder.
10/2004	The GABA-glutamate connection in schizophrenia: which is the proximate cause?
6/2004	The NMDA receptor glycine modulatory site: a therapeutic target for improving cognition and reducing negative symptoms in schizophrenia.

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Joseph T Coyle Research Topics

Disease

50	Schizophrenia (Dementia Praecox) 10/2022 - 01/2002
10	Cognitive Dysfunction 01/2021 - 01/2002
9	Psychotic Disorders (Schizoaffective Disorder) 01/2021 - 01/2002
4	Substance-Related Disorders (Drug Abuse) 01/2019 - 12/2006
4	Bipolar Disorder (Manic Depressive Psychosis) 11/2018 - 04/2003
3	Neurodevelopmental Disorders 10/2019 - 11/2007
3	AIDS-Related Complex (ARC) 01/2018 - 09/2014
3	Neurobehavioral Manifestations 01/2010 - 07/2006
2	Brain Diseases (Brain Disorder) 01/2021 - 01/2018
2	Mental Disorders (Mental Disorder) 01/2020 - 02/2015
2	Alzheimer Disease (Alzheimer's Disease) 10/2019 - 07/2007
2	Atrophy 01/2018 - 01/2015
2	Nervous System Diseases (Neurological Disorders) 01/2017 - 02/2012
2	Ganglion Cysts (Ganglion) 12/2011 - 12/2009
1	Disease Progression 10/2019
1	Amyloid Plaque 10/2019
1	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 01/2018
1	Traumatic Brain Injuries (Traumatic Brain Injury) 08/2017
1	Brain Injuries (Brain Injury) 08/2017
1	Glucose Intolerance 04/2015
1	Diabetes Complications 04/2015
1	Insulin Resistance 04/2015
1	Type 2 Diabetes Mellitus (MODY) 04/2015
1	Folic Acid Deficiency (Folic Acid Deficiencies) 06/2012
1	Ataxia (Dyssynergia) 06/2012
1	Infarction (Infarctions) 01/2010
1	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/2010
1	Stroke (Strokes) 01/2010
1	Brain Ischemia (Cerebral Ischemia) 01/2010
1	Rett Syndrome (Rett's Disorder) 11/2007
1	Angelman Syndrome (Syndrome, Angelman) 11/2007
1	Microcephaly 11/2007
1	Seizures (Absence Seizure) 11/2007
1	Neoplasms (Cancer) 09/2007

Drug/Important Bio-Agent (IBA)

35	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2021 - 01/2002
15	Serine (L-Serine)FDA Link 01/2021 - 12/2009
12	Glutamic Acid (Glutamate)FDA Link 01/2021 - 01/2004
12	Glycine (Aminoacetic Acid)FDA LinkGeneric 01/2018 - 04/2002
11	Antipsychotic Agents (Antipsychotics)IBA 11/2020 - 01/2002
9	serine racemaseIBA 01/2020 - 01/2010
8	N-Methylaspartate (NMDA)IBA 05/2015 - 04/2002
5	Dopamine (Intropin)FDA LinkGeneric 01/2021 - 04/2002
5	Proteins (Proteins, Gene)FDA Link 11/2018 - 10/2006
4	EnzymesIBA 10/2019 - 01/2011
4	gamma-Aminobutyric Acid (GABA)IBA 01/2019 - 10/2004
4	DysbindinIBA 11/2018 - 10/2006
4	ParvalbuminsIBA 01/2018 - 05/2008
4	Glutamate Receptors (Glutamate Receptor)IBA 03/2016 - 01/2002
4	Dissociative AnestheticsIBA 09/2012 - 04/2002
4	Ketamine FDA LinkGeneric 01/2012 - 01/2002
3	Biological ProductsIBA 10/2022 - 02/2015
3	Messenger RNA (mRNA)IBA 05/2015 - 01/2004
3	Dopamine D2 Receptors (Dopamine D2 Receptor)IBA 01/2010 - 01/2002
2	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2021
2	Cocaine (Cocaine HCl)IBA 01/2019 - 06/2015
2	Phosphotransferases (Kinase)IBA 01/2019 - 03/2015
2	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2018 - 01/2011
2	LithiumIBA 01/2017 - 04/2003
2	Glutamate Carboxypeptidase II (N-Acetylaspartylglutamate Peptidase)IBA 06/2012 - 01/2004
2	Folic Acid (Vitamin M)FDA LinkGeneric 06/2012 - 07/2005
2	Phencyclidine (Angel Dust)IBA 01/2012 - 01/2002
2	NeuregulinsIBA 01/2012 - 01/2011
2	Neurotransmitter Agents (Neurotransmitter)IBA 01/2012 - 05/2008
2	Nicotine FDA Link 05/2008 - 12/2006
1	Kynurenic Acid (Kynurenate)IBA 01/2020
1	Quinolinic AcidIBA 01/2020
1	Neuroprotective AgentsIBA 01/2020
1	Tryptophan (L-Tryptophan)FDA Link 01/2020
1	Glycine Dehydrogenase (Decarboxylating)IBA 10/2019
1	Amyloid (Amyloid Fibrils)IBA 10/2019
1	Protein Kinase CIBA 01/2019
1	CalciumIBA 01/2018
1	ChromatinIBA 01/2018
1	CytosineIBA 01/2018
1	Protons (Proton)IBA 01/2018
1	D-Aspartic Acid (D Aspartate)IBA 03/2016
1	Metabotropic Glutamate 5 ReceptorIBA 01/2016
1	IncretinsIBA 04/2015
1	Glucose (Dextrose)FDA LinkGeneric 04/2015
1	Diphtheria ToxinIBA 04/2015
1	TropomyosinIBA 03/2015
1	Dizocilpine Maleate (Dizocilpine)IBA 03/2015
1	trkB ReceptorIBA 03/2015
1	Aminobutyrates (Aminobutyric Acid)IBA 01/2015
1	Serotonin (5 Hydroxytryptamine)IBA 02/2014
1	Haloperidol (Haldol)FDA LinkGeneric 11/2013
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 07/2013
1	DNA (Deoxyribonucleic Acid)IBA 02/2012
1	D-Amino-Acid Oxidase (D-Amino Acid Dehydrogenase)IBA 01/2012
1	AMPA Receptors (AMPA Receptor)IBA 12/2011
1	Butyric Acid (Butanoic Acid)IBA 01/2011
1	Cholinergic Agents (Cholinergics)IBA 01/2010
1	Pharmaceutical PreparationsIBA 01/2010
1	Dopamine Receptors (Dopamine Receptor)IBA 01/2010
1	MicroRNAs (MicroRNA)IBA 03/2009
1	Therapeutic UsesIBA 05/2008
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 11/2007
1	Methyl-CpG-Binding Protein 2IBA 11/2007

Therapy/Procedure

1	Therapeutics 10/2019
1	Lasers (Laser) 01/2018